Inside Back Cover: Nickel‐Catalyzed Asymmetric Hydrogenation of N ‐Sulfonyl Imines (Angew. Chem. Int. Ed. 22/2019)

Spotlights on our sister journals: Angew. Chem. Int. Ed. 15/2018.

MAC it happen : Presented is a study of the synergistic structuredirecting effect of metal–amine complexes (MACs) with different chelating polyamine ligands and imidazolium-based ionic liquid (IL) cations. For the first time, a layered selenidostannate with an asymmetric eight-membered ring, an organic-decorated layered selenidostannate, and a 3D selenidostannate with both the MAC and IL cation...

Organocatalytic asymmetric transfer hydrogenation of imines

Highly enantioselective Pd-catalyzed asymmetric hydrogenation of activated imines.

Pd/bisphosphines complexes are highly effective catalysts for asymmetric hydrogenation of activated imines in trifluoroethanol. The asymmetric hydrogenation of N-diphenylphosphinyl ketimines 3 with Pd(CF3CO2)/(S)-SegPhos indicated 87-99% ee, and N-tosylimines 5 could gave 88-97% ee with Pd(CF3CO2)/(S)-SynPhos as a catalyst. Cyclic N-sulfonylimines 7 and 11 were hydrogenated to afford the useful...

Brønsted acid activation strategy in transition-metal catalyzed asymmetric hydrogenation of N-unprotected imines, enamines, and N-heteroaromatic compounds.

Asymmetric hydrogenation plays an important role in organic synthesis, but that of the challenging substrates such as N-unprotected imines, enamines, and N-heteroaromatic compounds (1H-indoles, 1H-pyrroles, pyridines, quinolines, and quinoxalines) has only received increased attention in the past three years. Considering the interaction modes of a Brønsted acid with a Lewis base, Brønsted acids...

Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst.

Chiral amines are often critical components of pharmaceutical agents. For example, about 15-25% of the singleenantiomer products in development contain this unit according to a recent analysis.1 The development of practical methods for the synthesis of enantiomerically pure amines is therefore of great interest. Traditional resolution methods and enzymatic transaminase technology are frequent c...